DORA

Investigator physician: Pr Antoine VERGER

Contribution of Cerebral ¹⁸F-DOPA PET-CT Scan in High-grade Recurrent Gliomas : a Monocentric Pilot Impact Study on the Practices of Defining Target Volumes Before RAdiotherapy

Gliioma

Pilot feasibility, interventional, non-randomized study to evaluate a medical device using a radiopharmaceutical: ¹⁸F-FDOPA.

Patients with high-grade glioma (WHO grade III or IV) at the stage of first local recurrence, for whom the indication of stereotactic radiotherapy alone has been validated by the neuro-oncology RCP, will be presented with the study.

Patients participating in the study will have :
- a cerebral MRI
- a centring brain scan
- positron emission tomography (PET/CT) with ¹⁸F-FDOPA.
Patients are then followed over 12 months with several brain MRI scans (every 3 months).

This study will make it possible to implement amino acid metabolic imaging in the definition of volumes to be irradiated in the recurrence of high-grade gliomas at the Nancy CHRU.

The treatment under study: Diagnostic PET/CT à la ¹⁸F-FDOPA
Study status: Recruiting
Clinical Trial number: NCT04766632
Funding: Clinical Research Program Contract of Nancy Hospital